- Modified release tablets in 500 mg and 1000 mg strengths.
- Unless specified by the brand modified released tablets should not be halved or crushed at any time.
- This form of Metformin has not been shown to have any increase in adverse effects compared to with the equivalent dose of the immediate release Metformin.
- There is data to suggest the modified release may cause less gastrointestinal side effects than the immediate release.
Inhibit the breakdown of dipeptidyl peptidase-4 enzyme (this enzyme is responsible for or the degradation of incretins such as GLP-1 which are a group of hormones that stimulate a decrease in blood glucose levels).
The most significant effect on glucose levels is after meals
Metformin modified release is not altered by the composition of a meal.
Plasma protein binding of metformin is negligible.
Renal clearance of metformin is > 400 mL/min, indicating that metformin is eliminated by glomerular filtration and tubular secretion. Dosage adjustment should occur therefore in those with renal dysfunction and ceased in renal failure.
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