Pharmacy Diabetes

Alpha-glucosidase Inhibitors Acarbose-overview-mode of actions

Alpha-glucosidase Inhibitors (AGIs) inhibit the absorption of carbohydrates from the small intestine by inhibiting alpha glucosidase, an intestinal enzyme that releases glucose from larger carbohydrates. By delaying carbohydrate absorption, they reduce the rise in postprandial blood glucose concentrations.
Since degradation of complex carbohydrates into glucose is prohibited, some carbohydrate will remain in the intestine and be flushed into the colon. Here bacteria digest the carbohydrates, leading to the common side effects including flatulence, bloating and diarrhoea.

Reduces postprandial glucose levels by inhibiting alpha-glucosidase enzymes in the small intestine, causing a delay in the absorption of carbohydrates.

Dose should be taken immediately before meals or with the first mouthful, up to three times a day.